OCA-B/Pou2af1 Expression in T Cells Promotes PD-1 Blockade-Induced Autoimmunity but is Dispensable for Anti-Tumor Immunity
Junhong Du, Asit Kumar Manna, Miguel A. Medina-Serpas, Erik P. Hughes, Paulla Bisoma, Kimberley J. Evason, Arabella Young, W. David Wilson, Todd M. Brusko, Abdelbasset A. Farahat, Dean R Tantin
This study shows OCA-B in T cells promotes ICI-induced autoimmunity but is not needed for anti-tumor immunity, suggesting it could be targeted to prevent autoimmunity without harming cancer treatments.
bioRxiv · Oct 22, 2025 · PreprintImmunology