ImmunologybioRxivPreprint
OCA-B/Pou2af1 Expression in T Cells Promotes PD-1 Blockade-Induced Autoimmunity but is Dispensable for Anti-Tumor Immunity
Junhong Du, Asit Kumar Manna, Miguel A. Medina-Serpas…·Dean R Tantin
This study shows OCA-B in T cells promotes ICI-induced autoimmunity but is not needed for anti-tumor immunity, suggesting it could be targeted to prevent autoimmunity without harming cancer treatments.
DOI 10.1101/2025.10.22.683978