AlfaDAX-Derived ActRIIA/B Antibody with Semaglutide Enhances Fat Loss and Improves Weight-Loss Quality in DIO Mice
Ning Zhang, Yongkang Long, Zhangzhan Xu, Gaojian Chen, Ao Wang, Weihai Chen, Zhongwei Chen, Zhiming Liang, Kingsley Leung, Liang Chen
This study develops an anti-ActRIIA/B antibody, AB130-165, which, when combined with semaglutide, leads to greater weight loss and better preservation of lean mass in diet-induced obese mice compared to monotherapy or bimagrumab combinations.
bioRxiv · Jul 13, 2026 · PreprintPharmacology & Toxicology