Generation of High-Affinity Anti-GIPR Antagonist Antibodies with Sustained and Non-rebound Weight Loss in DIO Mice by AlfaBodY
Yongkang Long, Zhangzhan Xu, Ning Zhang, Gaojian Chen, Weihai Chen, Zhongwei Chen, Ao Wang, Zhiming Liang, Yingya Wang, Yi Zeng, Kingsley Leung, Liang Chen
This study uses AI to design high-affinity anti-GIPR antibodies that induce sustained weight loss in obese mice without rebound.
bioRxiv · Apr 24, 2026 · PreprintPharmacology & Toxicology