Author

Zhiming Liang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:deep learning· 1

Frequent Co-Authors

Ao WangiD· 2 shared Gaojian Chen· 2 shared Kingsley Leung· 2 shared Liang CheniD· 2 shared Ning Zhang· 2 shared Weihai Chen· 2 shared Yongkang Long· 2 shared Zhangzhan Xu· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPharmacology & Toxicology

Ao WangORCID

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2 papers

Recent·Most cited

AlfaDAX-Derived ActRIIA/B Antibody with Semaglutide Enhances Fat Loss and Improves Weight-Loss Quality in DIO Mice

Ning Zhang, Yongkang Long, Zhangzhan Xu, Gaojian Chen, Ao Wang, Weihai Chen, Zhongwei Chen, Zhiming Liang, Kingsley Leung, Liang Chen

This study develops an anti-ActRIIA/B antibody, AB130-165, which, when combined with semaglutide, leads to greater weight loss and better preservation of lean mass in diet-induced obese mice compared to monotherapy or bimagrumab combinations.

bioRxiv · Jul 13, 2026 · PreprintPharmacology & Toxicology

Generation of High-Affinity Anti-GIPR Antagonist Antibodies with Sustained and Non-rebound Weight Loss in DIO Mice by AlfaBodY

Yongkang Long, Zhangzhan Xu, Ning Zhang, Gaojian Chen, Weihai Chen, Zhongwei Chen, Ao Wang, Zhiming Liang, Yingya Wang, Yi Zeng, Kingsley Leung, Liang Chen

This study uses AI to design high-affinity anti-GIPR antibodies that induce sustained weight loss in obese mice without rebound.

bioRxiv · Apr 24, 2026 · PreprintPharmacology & Toxicology