Helicobacter pylori vacuolating cytotoxin A exploits human endosomes for intracellular activation
Samuel Leslie Palframan, Md. Toslim Mahmud, Kher Shing Tan, Rhys Grinter, Vicky Xin, Rhys A. Dunstan, Diana Micati, Genevieve Kerr, Paul John McMurrick, Andrew Smith, Helen E. Abud, Thanh Ngoc Nguyen, Michael Lazarou, Oded Kleifeld, Trevor J. Lithgow, , Terry Kwok
This study identifies that Helicobacter pylori VacA is processed in endosomes by proteases into active forms that mediate intracellular effects, revealing a novel mechanism of toxin activation.
bioRxiv · Aug 22, 2022 · PreprintMolecular Biology