Author

Samuel Leslie Palframan

Monash UniversityORCID 0000-0002-9142-7629Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Andrew Smith· 1 shared Diana MicatiiD· 1 shared Genevieve KerriD· 1 shared Helen E. AbudiD· 1 shared Kher Shing TaniD· 1 shared Kipros Gabriel· 1 shared Md. Toslim Mahmud· 1 shared Michael LazarouiD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Andrew Smith

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1 paper

Recent·Most cited

Helicobacter pylori vacuolating cytotoxin A exploits human endosomes for intracellular activation

Samuel Leslie Palframan, Md. Toslim Mahmud, Kher Shing Tan, Rhys Grinter, Vicky Xin, Rhys A. Dunstan, Diana Micati, Genevieve Kerr, Paul John McMurrick, Andrew Smith, Helen E. Abud, Thanh Ngoc Nguyen, Michael Lazarou, Oded Kleifeld, Trevor J. Lithgow, , Terry Kwok

This study identifies that Helicobacter pylori VacA is processed in endosomes by proteases into active forms that mediate intracellular effects, revealing a novel mechanism of toxin activation.

bioRxiv · Aug 22, 2022 · PreprintMolecular Biology