Author

Andrew Smith

Cabrini Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Marieke OudelaariD· 1 shared Barbara XellaiD· 1 shared Caroline L. HarroldiD· 1 shared Christian BabbsiD· 1 shared Damien J. DownesiD· 1 shared Diana MicatiiD· 1 shared Douglas R. HiggsiD· 1 shared Genevieve KerriD· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

A. Marieke OudelaarORCID

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2 papers

Recent·Most cited

Helicobacter pylori vacuolating cytotoxin A exploits human endosomes for intracellular activation

Samuel Leslie Palframan, Md. Toslim Mahmud, Kher Shing Tan, Rhys Grinter, Vicky Xin, Rhys A. Dunstan, Diana Micati, Genevieve Kerr, Paul John McMurrick, Andrew Smith, Helen E. Abud, Thanh Ngoc Nguyen, Michael Lazarou, Oded Kleifeld, Trevor J. Lithgow, , Terry Kwok

This study identifies that Helicobacter pylori VacA is processed in endosomes by proteases into active forms that mediate intracellular effects, revealing a novel mechanism of toxin activation.

bioRxiv · Aug 22, 2022 · PreprintMolecular Biology

Multipartite super-enhancers function in an orientation-dependent manner

Mira T. Kassouf, Helena S. Francis, Matthew E. Gosden, Maria Suciu, Damien J. Downes, Caroline L. Harrold, Martin Larke, A. Marieke Oudelaar, Lucy Cornell, Joseph Blayney, Jelena M. Telenius, Barbara Xella, Yuki Shen, Nikolaos Sousos, Jacqueline A. Sharpe, , Douglas R. Higgs

The paper shows that super-enhancers function directionally and orientation-dependently, unlike regular enhancers, by analyzing the β-globin super-enhancer.

bioRxiv · Jul 14, 2022 · PreprintMolecular Biology