Author
The University of MelbourneORCID 0000-0001-9698-0020Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Elias Adriaenssens, Stefan Schaar, Annan SI Cook…·Sascha Martens
Annan SI Cook, Minghao Chen, Thanh Ngoc Nguyen…·James H. Hurley
This study maps the structural pathway of class III PI 3-kinase activation by showing how N-myristoylation of VPS15 stabilizes the inactive conformation and how GTP binding promotes activation.
Wai Kit Lam, Runa S. J. Lindblom, Bridget Milky…·Michael Lazarou
The paper identifies presynapses as sites of mitophagy in neurons and shows their role in preventing axon degeneration when mitophagy is defective.
Elias Adriaenssens, Thanh Ngoc Nguyen, Justyna Zofia Sawa-Makarska…·Sascha Martens
This study identifies NAP1 and SINTBAD as regulators of mitophagy, inhibiting OPTN-driven initiation while promoting NDP52-driven progression.
Zhong Yan Gan, Sylvie Callegari, Thanh Ngoc Nguyen…·David Komander
The paper investigates PINK1's interaction with nucleotides and kinetin, revealing structural changes and binding constraints that affect its activity and mitophagy.
Samuel Leslie Palframan, Md. Toslim Mahmud, Kher Shing Tan…·Terry Kwok
This study identifies that Helicobacter pylori VacA is processed in endosomes by proteases into active forms that mediate intracellular effects, revealing a novel mechanism of toxin activation.