Helen E. Abud

This paper introduces Airy beam light sheet microscopy to image subcellular dynamics in large tissues with high spatial and temporal resolution across multiple organisms and biological processes.

This paper creates a spatial atlas of colorectal cancer and normal colon, identifying nine niches and their gene expression profiles, and links stromal changes to tumour differentiation.

This study shows that an APC truncation mutant increases epithelial tissue tension via RhoA/ROCK, impairing apical cell extrusion and potentially contributing to disease.

This study identifies that Helicobacter pylori VacA is processed in endosomes by proteases into active forms that mediate intracellular effects, revealing a novel mechanism of toxin activation.

This study shows that alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation through opposing functions of Grh.O and Grh.N.