Trevor J. Lithgow

Unlocking the secrets of paired terminal genomic repeats utilised by the Burkholderia jumbo phage Matilda

This study identifies a novel jumbo phage with a tripartite genome architecture and describes its terminal elements' role in infection.

Integrated cross-sectoral surveillance of antimicrobial resistance genotypes and phenotypes across disparate reservoirs

This study integrates surveillance methods to profile AMR genotypes and phenotypes across diverse environmental and clinical samples, revealing high diversity and mismatches between genotype and phenotype.

Paired in situ and molecular analyses identify mechanisms of pathogen persistence within environmental communities

The paper identifies genes and mechanisms enabling pathogen persistence in freshwater ecosystems using paired in situ and molecular analyses of Escherichia, Klebsiella, and Enterococcus.

Helicobacter pylori vacuolating cytotoxin A exploits human endosomes for intracellular activation

This study identifies that Helicobacter pylori VacA is processed in endosomes by proteases into active forms that mediate intracellular effects, revealing a novel mechanism of toxin activation.