Lipid Droplet Remodeling Safeguards Redox Balance through the DGAT1-PANK2-NRF2 Axis in Mammalian Oocytes and Drives Age-Associated Decline
Pravin Birajdar, Akshay Kumar, Anjali Kumari, Aradhana Mohanty, Mohd Athar, Ajith Kumar, Kiran Kumar P., S Abhilasha, Sahina Sabnam, Silambresan Y, Ankita Verma, Menda Rajendar, H. B. D. Prasada Rao
This study identifies the DGAT1-PANK2-NRF2 axis as critical for lipid droplet remodeling, redox balance, and oocyte quality, with dysfunction linked to age-related decline.
bioRxiv · Nov 28, 2025 · PreprintCell Biology