H. B. D. Prasada Rao

This study identifies HIPK2 and IKKβ as kinases that phosphorylate TAp63α, stabilizing it during the oocyte DNA damage response and enhancing oocyte survival.

This study identifies CDK1 as a critical regulator of DNA repair in dictyate-arrested oocytes, showing it facilitates RAD51-mediated homologous recombination to protect against genotoxic stress.

This study shows SUMO levels correlate with crossover rates across vertebrate species and within goat breeds, suggesting SUMO modulates meiotic crossover variation.

This study shows SUMO regulates meiotic chromosome length and crossover rate in mice by affecting chromatin loop and axis organization.

This study identifies the DGAT1-PANK2-NRF2 axis as critical for lipid droplet remodeling, redox balance, and oocyte quality, with dysfunction linked to age-related decline.

This paper develops a brain delivery system using RVG29-conjugated chitosan nanoparticles to deliver kisspeptin agonists and antagonists, showing enhanced brain accumulation and effective modulation of reproductive functions.

This study identifies Cathepsin B's role in regulating ovarian reserve through mitophagy and IGF1R turnover, showing its conservation in higher vertebrates.

This study identifies phosphorylation of Mps3's luminal region as critical for its nuclear envelope localization during meiosis, mediated by CDK and DDK.

This study shows RNF212 mediates oocyte quality control by impeding DNA break repair during meiosis, ensuring defective eggs are eliminated.

This study shows that MutSγ activation during meiosis depends on Cdc7-mediated phosphorylation of Msh4, stabilizing the complex and enabling crossover formation.

The paper shows that SUMO and ubiquitin-proteasome systems regulate meiotic prophase events in mouse by controlling protein turnover through RNF212 and HEI10.