A Rapid and Universal Pipeline for High-Resolution GPCR Structure Determination through In Silico Construct Optimization and de novo Protein Design
Asato Kojima, Kouki Kawakami, Naoya Kobayashi, Kazuhiro Kobayashi, Toshiki E. Matsui, Kohei Uemoto, Yuzhong Gu, Masahiro Fukuda, Hideaki E. KATO
This paper introduces a pipeline combining AI-assisted construct screening and de novo protein design to rapidly determine high-resolution GPCR structures, validated on multiple receptors.
bioRxiv · Apr 6, 2026 · PreprintBiophysics