Hideaki E. KATO

A Rapid and Universal Pipeline for High-Resolution GPCR Structure Determination through In Silico Construct Optimization and de novo Protein Design

This paper introduces a pipeline combining AI-assisted construct screening and de novo protein design to rapidly determine high-resolution GPCR structures, validated on multiple receptors.

Structural basis for color tuning and passive ion conductance in red-shifted pump-fold channelrhodopsin ChR024

This study presents cryo-EM structures of ChR024, revealing its color-tuning mechanism and transition from a proton pump to a light-gated channel.

Functional characterization of red-shifted rhodopsin channels from giant viruses explored by a machine-learning model for long-wavelength optogenetics

The paper uses a machine-learning model to predict red-shifted channelrhodopsin variants, identifying ChR024 with a maximum absorption wavelength of ~578 nm for optogenetics.