Author

Kazuhiro Kobayashi

Research Center for Advanced Science and Technology, The University of TokyoORCID 0000-0002-3366-3586Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Assay:protein structure· 1

Frequent Co-Authors

Asato KojimaiD· 1 shared Asuka InoueiD· 1 shared Francois Marie Ngako KadjiiD· 1 shared Hideaki E. KATOiD· 1 shared Junken AokiiD· 1 shared Kohei Uemoto· 1 shared Kouki KawakamiiD· 1 shared Masahiro FukudaiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiophysics

Asato KojimaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A Rapid and Universal Pipeline for High-Resolution GPCR Structure Determination through In Silico Construct Optimization and de novo Protein Design

Asato Kojima, Kouki Kawakami, Naoya Kobayashi, Kazuhiro Kobayashi, Toshiki E. Matsui, Kohei Uemoto, Yuzhong Gu, Masahiro Fukuda, Hideaki E. KATO

This paper introduces a pipeline combining AI-assisted construct screening and de novo protein design to rapidly determine high-resolution GPCR structures, validated on multiple receptors.

bioRxiv · Apr 6, 2026 · PreprintBiophysics

Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein.

Kazuhiro Kobayashi, Wataru Shihoya, Tomohiro Nishizawa, Francois Marie Ngako Kadji, Junken Aoki, Asuka Inoue, Osamu Nureki

The paper presents a cryo-EM structure of the human PAC1 receptor bound to PACAP and an engineered Gs heterotrimer, revealing functional differences in the ECD between PAC1R and GLP1R.

Nature Structural & Molecular Biology · Mar 1, 2020Peer-reviewedMolecular Biology