Novel RNA Polymerase I and Cyclin Dependent Kinase combination therapy for the treatment of aggressive Acute Myeloid Leukemia.
Nadine Hein, Perlita Poh, Jason A. Powell, Lorena Núñez-Villacís, Sarah Sant’Anna Maranhão, Maurits Evers, Jirawas Sornkom, Victoria S. Pope, Priscilla Soo, Adrià Closa, Jasmina Frawley, Sheren J. Al-Obaidi, Cathryn M. Gould, Piyush B. Madhamshettiwar, Kaylene J. Simpson, , Rita Ferreira
This paper identifies a synergistic combination of RNA Polymerase I inhibitor CX-5461 and CDK inhibitor Dinaciclib that enhances therapeutic efficacy in AML by inducing nucleolar stress and cell cycle arrest.
Leukemia · Oct 8, 2026Peer-reviewedCancer Biology