Author

Cathryn M. Gould

Garvan Institute of Medical Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Phuc‐Loi LuuiD· 3 shared Susan J. ClarkiD· 3 shared Catherine Elizabeth CaldoniD· 2 shared Clare StirzakeriD· 2 shared Elena ZotenkoiD· 2 shared Joanna Achinger-KaweckaiD· 2 shared Nicola J. ArmstrongiD· 2 shared Qian DuiD· 2 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMolecular Biology

Phuc‐Loi LuuORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Novel RNA Polymerase I and Cyclin Dependent Kinase combination therapy for the treatment of aggressive Acute Myeloid Leukemia.

Nadine Hein, Perlita Poh, Jason A. Powell, Lorena Núñez-Villacís, Sarah Sant’Anna Maranhão, Maurits Evers, Jirawas Sornkom, Victoria S. Pope, Priscilla Soo, Adrià Closa, Jasmina Frawley, Sheren J. Al-Obaidi, Cathryn M. Gould, Piyush B. Madhamshettiwar, Kaylene J. Simpson, , Rita Ferreira

This paper identifies a synergistic combination of RNA Polymerase I inhibitor CX-5461 and CDK inhibitor Dinaciclib that enhances therapeutic efficacy in AML by inducing nucleolar stress and cell cycle arrest.

Leukemia · Oct 8, 2026Peer-reviewedCancer Biology

DNA methylation is required to maintain DNA replication timing precision and 3D genome integrity

Qian Du, Grady C. Smith, Phuc‐Loi Luu, James M. Ferguson, Nicola J. Armstrong, Catherine Elizabeth Caldon, Elyssa M. Campbell, Shalima S. Nair, Elena Zotenko, Cathryn M. Gould, Michael J Buckley, Kee-Ming Chia, Neil Portman, Elgene Lim, Dominik C. Kaczorowski, , Susan J. Clark

This study shows DNA hypomethylation disrupts replication timing precision and 3D genome organisation in colorectal cancer DNMT1 and DNMT3B knockout cells.

Cell Reports · Sep 1, 2021Peer-reviewedMolecular Biology

BRG1 promotes transcriptional patterns that are permissive to proliferation in cancer cells

Katherine A. Giles, Cathryn M. Gould, Joanna Achinger-Kawecka, Scott G. Page, Georgia Rose Kafer, Phuc‐Loi Luu, Anthony J. Cesare, Susan J. Clark, Phillippa C. Taberlay

This study shows BRG1 promotes proliferation in prostate cancer by regulating gene expression related to cell cycle and DNA replication, independent of AR and FOXA1.

bioRxiv · Jul 3, 2020 · PreprintMolecular Biology

Replication timing shapes the cancer epigenome and the nature of chromosomal rearrangements

Qian Du, Saul A. Bert, Nicola J. Armstrong, Catherine Elizabeth Caldon, Jenny Z. Song, Shalima S. Nair, Cathryn M. Gould, Phuc‐Loi Luu, Amanda Khoury, Wenjia Qu, Elena Zotenko, Clare Stirzaker, Susan J. Clark

This study shows that replication timing influences epigenetic changes and chromosomal rearrangements in cancer by linking early and late replication to specific methylation and histone modifications.

bioRxiv · Jan 22, 2018 · PreprintGenomics