Author

Jason A. Powell

South Australia PathologyORCID 0000-0001-8493-9178Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Stuart Maxwell PitsoniD· 2 shared Adrià ClosaiD· 1 shared Alexander Charles LewisiD· 1 shared Alexandra M. Birrell· 1 shared Amee J. GeorgeiD· 1 shared Andrew H. WeiiD· 1 shared Ann E. FrazieriD· 1 shared Annette E. Trickett· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

Stuart Maxwell PitsonORCID

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3 papers

Recent·Most cited

Cancer BiologyLeukemiaPeer-reviewedOct 8, 2026

Novel RNA Polymerase I and Cyclin Dependent Kinase combination therapy for the treatment of aggressive Acute Myeloid Leukemia.

Nadine Hein, Perlita Poh, Jason A. Powell…·Rita Ferreira

This paper identifies a synergistic combination of RNA Polymerase I inhibitor CX-5461 and CDK inhibitor Dinaciclib that enhances therapeutic efficacy in AML by inducing nucleolar stress and cell cycle arrest.

DOI 10.1038/s41375-026-03148-1

humanmouse

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Cancer BiologyCellPeer-reviewedNov 19, 2025

Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukaemia.

Alexander Charles Lewis, Emily Gruber, Rheana L. Franich…·Lev M. Kats

This study identifies heme biosynthesis as a selective dependency in AML, showing that its inhibition triggers cuproptosis via copper accumulation and reveals synthetic lethal pathways for therapeutic strategies.

38 citationstop 1%

mousehuman

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Developmental BiologybioRxivPreprintApr 18, 2023

Cell Type-Specific Regulation by a Heptad of Transcription Factors in Human Hematopoietic Stem and Progenitor Cells

Shruthi Subramanian, Julie A.I. Thoms, Yizhou Huang…·John E. Pimanda

The paper identifies cell-type-specific regulatory roles of a heptad of transcription factors in human hematopoietic stem and progenitor cells.

DOI 10.1101/2023.04.18.537282

humanbulk RNA-seq

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