Glutamate transporter xCT is important for cGAS-dependent interferon responses to DNA and to HSV-1
Julia Blay‐Cadanet, Maria Lange Pedersen, Alice Pedersen, Maja Hemberg, Krishna Twayana, Jacob Storgaard, Cecilie Siem Bach-Nielsen, Anne L. Thielke, Cecilie Poulsen, Christoph F. Kollmann, Ensieh Farahani, Michael Lappé, Marie Beck Iversen, Qi Wu, Camilla Bak Nielsen, , Christian Kanstrup Holm
This study shows that the xCT transporter regulates cGAS-dependent interferon responses to DNA and HSV-1 by controlling glutamate levels and cGAMP production.
bioRxiv · Apr 30, 2026 · PreprintImmunology