Single-Cell RNA Sequencing Reveals Commensal Microbes Amplify Sex-Specific Immune Programming in the Murine Lung
Alexandra Melton, Krista Ferrari, Joseph P. Hoffmann, Kejing Song, Jay K. Kolls, Janet E. McCombs
This study uses scRNA-seq and flow cytometry to show that commensal microbes amplify sex-specific immune differences in the murine lung, with males showing myeloid bias and females lymphocyte skewing under SPF conditions.
bioRxiv · Jan 24, 2026 · PreprintImmunology