Joseph P. Hoffmann

This study identifies intrinsic T-cell programming and pulmonary immune spatial organization as sex-dependent mechanisms governing tuberculosis immunity in mice.

This study shows that gonadal sex, not chromosomal sex, influences TB susceptibility in mice, with males showing myeloid dysfunction and females showing enhanced immune responses.

This study uses scRNA-seq and flow cytometry to show that commensal microbes amplify sex-specific immune differences in the murine lung, with males showing myeloid bias and females lymphocyte skewing under SPF conditions.

This study infects pregnant mice with Plasmodium berghei at different gestational stages to investigate how placental malaria affects perinatal outcomes and identifies immune and hormonal changes associated with adverse effects.