Dirk Hubmacher

This study identifies dysregulated TGFβ-ERK signaling as a driver of aberrant extracellular matrix production in Noonan syndrome-associated pulmonary valve stenosis using iPSC models and patient tissue.

This study shows that inactivating both ADAMTS10 and ADAMTS17 in mice causes severe bone shortening and skin issues, suggesting they regulate ECM formation and chondrocyte function.

This study identifies TGFβ signaling as critical for neonatal tendon regeneration by promoting tenocyte recruitment and functional recovery.

This study shows that ADAMTSL2 deletion in limb soft tissues, particularly tendons, causes disproportionate limb shortening by affecting tendon growth and fibrillin microfibril formation, suggesting a new mechanism for geleophysic dysplasia.