Recapitulating physiologically relevant oxygen levels and extracellular matrix remodeling in patient-derived tumor-immune tunable models reveal targeting opportunities for immunologically cold high-grade serous tumors
Simona Plesselova, Hailey Axemaker, Kristin Calar, Oduduabasi Isaiah, Jared W. Wollman, Somshuvra Bhattacharya, Etienne Z. Gnimpiéba, Darci M. Fink, Congzhou Wang, Maria Bell, Pilar de la Puente
This study develops patient-derived tumor-immune models that mimic hypoxia and extracellular matrix changes, revealing TGF-β targeting opportunities to improve immune infiltration in cold tumors.
bioRxiv · Jun 23, 2025 · PreprintBioengineering