Darci M. Fink

Ift43 Controls the Ciliary Levels of Gli2 and Gli3

This study shows that Ift43 regulates Gli2 and Gli3 levels in cilia, affecting Hedgehog signaling and causing developmental defects in mice.

Recapitulating physiologically relevant oxygen levels and extracellular matrix remodeling in patient-derived tumor-immune tunable models reveal targeting opportunities for immunologically cold high-grade serous tumors

This study develops patient-derived tumor-immune models that mimic hypoxia and extracellular matrix changes, revealing TGF-β targeting opportunities to improve immune infiltration in cold tumors.

IFT20 regulates lymphatic endothelial cell-cell junctions via endocytic trafficking of VE-cadherin

This study shows that IFT20 regulates VE-cadherin localization at lymphatic endothelial cell junctions, affecting lymphangiogenesis and lymph drainage.

Multicompartmentalized microvascularized tumor-on-a-chip to study tumor-stroma interactions and drug resistance in ovarian cancer

This paper develops a tumor-on-a-chip model to study ovarian cancer drug resistance by mimicking tumor-stroma interactions and compartmentalized microenvironment.