Global loss of cellular m6A RNA methylation following infection with different SARS-CoV-2 variants
Roshan Vaid, Akram Mendez, Ketan Thombare, Rebeca Burgos‐Panadero, Rémy Robinot, Bárbara F. Fonseca, Nikhil R. Gandasi, Johan Ringlander, Mohammad Hassan Baig, Jae-June Dong, Y. Choi, Björn Reinius, Lisa A. Chakrabarti, Kristina Nystrom, Tanmoy Mondal
The paper shows SARS-CoV-2 variants reduce m6A RNA methylation in host cells, affect METTL3 localization, and impair stress granules, with XPO1 inhibition reversing some effects.
bioRxiv · Dec 8, 2022Molecular Biology