Roshan Vaid

Stealth replication of SARS-CoV-2 Omicron in the nasal epithelium at physiological temperature

This study shows that the SARS-CoV-2 Omicron variant replicates more efficiently and evades innate immune responses in a nasal epithelium model at physiological temperature.

Telomeric Repeat-Containing lncRNA TERRA Targets Non-Telomeric DNA in Trans via R-Loops

The paper identifies TERRA's ability to bind non-telomeric DNA via R-loops, suggesting a role in genome-wide gene regulation.

Comprehensive interrogation of a Drosophila embryonic patterning network reveals the impact of chromatin state on tissue-specific burst kinetics and RNA Polymerase II promoter-proximal pause release

The paper investigates how chromatin state influences transcriptional burst kinetics and RNA Polymerase II pausing during Drosophila embryonic patterning.

Global loss of cellular m6A RNA methylation following infection with different SARS-CoV-2 variants

The paper shows SARS-CoV-2 variants reduce m6A RNA methylation in host cells, affect METTL3 localization, and impair stress granules, with XPO1 inhibition reversing some effects.

Independence of 3D chromatin conformation and gene regulation during Drosophila dorsoventral patterning

The paper shows that 3D chromatin organisation and gene regulation are independent during Drosophila dorsoventral patterning, with chromatin structure maintaining consistency across tissues despite differences in gene expression.