Björn Reinius

The paper investigates transcriptional responses to autosomal aneuploidies and finds evidence for global dosage compensation across aneuploid chromosomes.

This study identifies Z-chromosome dosage compensation and sex-specific long non-coding RNAs in octopus, revealing evolutionary conservation of dosage compensation mechanisms.

This paper introduces a synthetic thermostable RNase inhibitor that improves single-cell RNA-seq library quality, reproducibility, and workflow flexibility compared to protein-based inhibitors.

The paper examines dosage compensation mechanisms on the avian Z chromosome in female, male, and intersex chickens, revealing transcriptional and translational strategies similar to mammalian X-chromosome compensation.

Voltage-Seq enables targeted single-cell transcriptome profiling of postsynaptic neurons based on specific voltage response types using all-optical voltage imaging and a connectome database.

Voltage-Seq enables targeted single-cell RNA-sequencing of neurons based on their postsynaptic response types using all-optical voltage imaging and a connectome-guided analysis tool.

The paper identifies six glutamatergic neuron types in the LHA-LHb pathway, showing that Esr1+ neurons induce aversion and are involved in stress sensitivity in female mice.

The paper shows SARS-CoV-2 variants reduce m6A RNA methylation in host cells, affect METTL3 localization, and impair stress granules, with XPO1 inhibition reversing some effects.

This study uses allele-resolved single-cell multi-omics to reveal the dynamics and transcriptional kinetics of X-chromosome upregulation in mouse development.

This study investigates the transcriptional dynamics and functions of long non-coding RNAs using single-cell RNA-seq, revealing distinct burst kinetics and cell-state specific roles.

Smart3-ATAC enables joint analysis of mRNA and chromatin accessibility in single cells with higher yield than existing droplet multiome methods.

This study shows transcriptional bursts explain autosomal monoallelic expression and influence allelic imbalance in scRNA-seq data.

The paper analyzes allele-specific scRNA-seq data to show that X-chromosome upregulation in mouse cells occurs through increased transcriptional burst frequency.

The paper reanalyzes previous findings on X-linked gene expression in human preimplantation embryos and challenges a recent reanalysis that disputes biallelic expression dampening.

This study compares five scRNA-seq protocols using mouse embryonic stem cells, finding Smart-seq2 most sensitive and SCRB-seq/Drop-seq most cost-efficient for differential gene detection.