Brd4-bound enhancers drive cell intrinsic sex differences in glioblastoma
Najla Kfoury, Zongtai Qi, Briana C. Prager, Michael Wilkinson, Lauren Broestl, Kristopher Berrett, Arnav Moudgil, Sumithra Sankararaman, Xuhua Chen, Jason Gertz, Jeremy N. Rich, Robi David Mitra, Joshua B. Rubin
This study identifies sex differences in glioblastoma driven by Brd4-bound enhancers, showing opposing responses to BET inhibitors in male and female tumor cells.
Proceedings of the National Academy of Sciences · Apr 13, 2021Peer-reviewedGenomics