Arnav Moudgil

Calling Cards: a customizable platform to longitudinally record protein-DNA interactions over time in cells and tissues

Calling Cards records protein-DNA interactions over time using transposons, enabling analysis of historical molecular states through sequencing.

Measuring transcription factor binding and gene expression using barcoded self-reporting transposon calling cards and transcriptomes

This paper introduces barcoded self-reporting transposon calling cards to efficiently measure transcription factor binding and gene expression in bulk populations, demonstrating their use in vitro and in vivo.

Brd4-bound enhancers drive cell intrinsic sex differences in glioblastoma

This study identifies sex differences in glioblastoma driven by Brd4-bound enhancers, showing opposing responses to BET inhibitors in male and female tumor cells.

The qBED track: a novel genome browser visualization for point processes

The paper introduces the qBED format and track for visualizing calling card data and other genomic datasets in the WashU Epigenome Browser.

Self-reporting transposons enable simultaneous readout of gene expression and transcription factor binding in single cells

This paper introduces self-reporting transposons (SRTs) and the scCC assay to simultaneously capture gene expression and TF binding in single cells, demonstrating their use in cultured cells and mouse cortex.

A viral toolkit for recording transcription factor-DNA interactions in live mouse tissues

The paper introduces FLEX Calling Cards, a method to map transcription factor-DNA interactions in specific cell types within heterogeneous tissues using viral delivery and transposon insertion.