Serial femtosecond crystallography reveals the pH-driven allosteric mechanism of hexamer glargine
Esra Beyarslan Ayan, Madan Kumar Shankar, Elek Telek, Jungmin Kang, Krisztian Fintor, T. Yabuuchi, Makina Yabashi, Takehiko Tosha
This study reveals the pH-driven allosteric mechanism of hexamer glargine using serial femtosecond crystallography and multiscale analyses, showing a structural transition linked to delayed release.
bioRxiv · Apr 10, 2026 · PreprintBiophysics