Makina Yabashi

Serial femtosecond crystallography reveals the pH-driven allosteric mechanism of hexamer glargine

This study reveals the pH-driven allosteric mechanism of hexamer glargine using serial femtosecond crystallography and multiscale analyses, showing a structural transition linked to delayed release.

Reciprocal-space mapping of diffuse scattering by serial femtosecond crystallography reveals analog-specific disorder in insulin analogs

This study compares structural heterogeneity of insulin analogs using crystallographic analysis across different temperatures, revealing analog-specific disorder patterns.

Compact Tape-Driven Sample Delivery System for Serial Femtosecond Crystallography

The paper introduces a compact tape-driven system for serial femtosecond crystallography that delivers sample droplets and initiates reactions, enabling efficient data collection.

Deciphering the altered conformational states of bifunctional thaumarchaeal crotonyl-CoA hydratase and 3-hydroxypropionyl-CoA dehydratase from Nitrosopumilus maritimus

The paper determines ambient temperature structures of the bifunctional Nmar_1308 enzyme from Nitrosopumilus maritimus, revealing new conformational dynamics relevant to synthetic biology.

Experimental and Computational Insights into the Structural Dynamics of the Fc Fragment of IgG1 Subtype from Biosimilar VEGF-Trap

This study presents near-physiological structures of the Fc fragment from a biosimilar VEGF-Trap and shows structural plasticity through molecular dynamics simulations.

High throughput protein serial crystallography using a grease matrix and a large-area support film

The paper introduces a new method for high-throughput protein serial crystallography using a grease matrix and a large-area support film to improve efficiency and reduce sample consumption.