Membrane Interfacial Potential Governs Surface Condensation and Fibrillation of α-Synuclein in Neurons
Jafarulla Shaikh, Aniruddha Nagarajan, Tuhina Mitra, Aninda Sundar Modak, Krittika Biswas, Geetanjali Meher, Aher Jayesh Bhausaheb, Nimal Archish Kannan, Bhavani Shankar Sahu, Swagata Ghatak, Sandeep Choubey, Mohammed Saleem
This study shows that lipid membrane interfaces drive α-synuclein condensation and fibrillation at low concentrations, revealing a mechanism for its propagation in neurodegeneration.
Nature Communications · Mar 19, 2026Peer-reviewedBiophysics