Declines in mRNA synthesis set the rate of organismal aging
Andrea Del Carmen-Fabregat, Natasha Oswal, Kshitij Sinhai, Jeremy Vicencio, Ryan Abramowitzi, Matthias Eder, Oguzhan Begik, Lucia Sedlackova, Eva Maria Novoa, Nicholas Stroustrup
The paper shows that declining mRNA synthesis capacity during aging reduces mRNA abundance, driving organismal aging, and that manipulating this decline affects healthspan and lifespan.
bioRxiv · Aug 17, 2026 · PreprintSystems Biology