Matthias Eder

The paper shows that declining mRNA synthesis capacity during aging reduces mRNA abundance, driving organismal aging, and that manipulating this decline affects healthspan and lifespan.

The paper assesses PTEN variant functionality across species, showing context-dependent oncogenicity and interindividual variability using C. elegans and cell lines.

STOMP-seq improves RNA-sequencing scalability by enabling 12-fold multiplexing through sample-specific barcodes, reducing costs and complexity for large-scale transcriptomic studies.

This paper improves the auxin-inducible degron system for precise in vivo protein degradation in C. elegans, enabling quantitative studies of cellular and systems dynamics.

This study shows C. elegans uses temperature-sensing neurons to preemptively activate defenses against hydrogen peroxide, which becomes more reactive at higher temperatures.

The paper identifies a neuronal circuit in C. elegans that modulates hydrogen peroxide defenses based on sensory input and bacterial presence.