Jeremy Vicencio

Declines in mRNA synthesis set the rate of organismal aging

The paper shows that declining mRNA synthesis capacity during aging reduces mRNA abundance, driving organismal aging, and that manipulating this decline affects healthspan and lifespan.

Ether lipid remodeling during neuronal differentiation prevents ferroptosis

This study shows that ether lipid remodeling during neuronal differentiation prevents ferroptosis by balancing pro- and anti-ferroptotic effects through vinyl ether bonds.

Engineering the auxin-inducible degron system for tunable in vivo control of organismal physiology

This paper improves the auxin-inducible degron system for precise in vivo protein degradation in C. elegans, enabling quantitative studies of cellular and systems dynamics.

Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes

This study demonstrates the use of SpG and SpRY CRISPR-Cas9 variants in zebrafish and C. elegans for genome editing, showing improved accessibility to previously uneditable sites.

Efficient generation of endogenous fluorescent reporters by Nested CRISPR in Caenorhabditis elegans

The paper introduces a cloning-free Nested CRISPR method for efficiently generating endogenous fluorescent reporters in C. elegans with high editing efficiency.