Vault Packaging Dynamics: Cargo Loading Stabilizes MVP Conformation for High-Payload Cytokine Delivery in Cancer Therapy
Leonard H. Rome, Qing Lou, Zachary M. Miller, Abby Zhaoqing Wang, Kushal Baranwal, Randall McNally, Z. Hong Zhou, Evan R. Williams
This study characterizes the structural dynamics of recombinant vaults, showing that cargo loading stabilizes their conformation for high-payload cytokine delivery in cancer therapy.
bioRxiv · Oct 29, 2026 · PreprintCell Biology