EWSR1::ATF1 hyperactivation via TRIM11 depletion triggers lethal metabolic rewiring in clear cell sarcoma
Wenxin Chao, Kilian Bales, Kamini Kaushal, Laura Mayerhofer, Julien Picotto, Akanksha Farswan, Christopher Davies, Dawid Krzeciesa, Susanne Grunewald, Francisco Yanqui-Rivera, Nicola Biondi, Liang Chen, Adarsh raveendran, Anushka Deshpande, Kwang Seok Lee, , Priya Chudasama
This study identifies TRIM11 as a regulator of EWSR1::ATF1 stability in clear cell sarcoma, showing its depletion leads to metabolic rewiring and cell death, with PCK1 as a potential biomarker.
bioRxiv · Nov 10, 2026 · PreprintCancer Biology