Discovery of target genes and pathways of blood trait loci using pooled CRISPR screens and single cell RNA sequencing
John A. Morris, Christina M. Caragine, Zharko Daniloski, Júlia Domingo, Timothy Barry, Lu Lu, Kyrie Davis, Marcello Ziosi, Dafni A. Glinos, Stephanie Hao, Eleni P. Mimitou, Peter Smibert, Kathryn Roeder, Eugene Katsevich, Tuuli Lappalainen, Neville E. Sanjana
The paper identifies target genes and pathways of blood trait loci using CRISPR screens and single-cell RNA sequencing, revealing cis and trans regulatory effects of noncoding variants.
Science · May 4, 2023Peer-reviewedGenomics