Author

Kyuhwan Shim

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Moe R. MahjoubiD· 2 shared Tao ChengiD· 2 shared Aruljothi MariappaniD· 1 shared Baolin WangiD· 1 shared Chidera AgwuiD· 1 shared Ewa LangneriD· 1 shared Jay GopalakrishnaniD· 1 shared Sanjay R. JainiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 19 mutual co-author links

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2 shared papersDevelopmental Biology

Moe R. MahjoubORCID

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2 papers

Recent·Most cited

Aberrant centrosome biogenesis disrupts nephron progenitor cell renewal and fate resulting in fibrocystic kidney disease

Tao Cheng, Chidera Agwu, Kyuhwan Shim, Baolin Wang, Sanjay R. Jain, Moe R. Mahjoub

This study shows that disrupting centrosome biogenesis in nephron progenitor cells causes kidney developmental defects and fibrocystic disease through reduced cell populations, premature differentiation, and altered signaling pathways.

bioRxiv · Apr 4, 2023 · PreprintDevelopmental Biology

Inhibition of Centrosome Clustering Reduces Cystogenesis and Improves Kidney Function in Autosomal Dominant Polycystic Kidney Disease

Tao Cheng, Aruljothi Mariappan, Ewa Langner, Kyuhwan Shim, Jay Gopalakrishnan, Moe R. Mahjoub

This study shows that inhibiting centrosome clustering reduces cyst growth and improves kidney function in ADPKD by activating p53-mediated apoptosis.

bioRxiv · Nov 16, 2022 · PreprintDevelopmental Biology