Moe R. Mahjoub

Progressive Actomyosin Remodeling Defining a Structured Podocyte Injury Response in Nephrotic Syndrome

This study identifies three sequential stages of actomyosin remodeling in podocyte injury across multiple kidney diseases, suggesting a structured, potentially reversible response.

Automated Ventricle Assessment via Three-dimensional Anatomical Reconstruction (AVA-TAR): a computational toolkit for autonomous lateral ventricle assessment in preclinical hydrocephalus models

This paper develops a deep learning tool for automated segmentation and morphological analysis of lateral ventricles in rodent MRIs, achieving high accuracy and correlation with manual measurements.

Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy

The paper identifies cellular defects beyond motility loss in ciliopathies caused by CCDC39/CCDC40 variants, showing proteostasis disruption and cell fate switching.

Cilia dysfunction in the lateral ventricles after neonatal intraventricular hemorrhage does not lead to functional changes in cilia-based CSF flow networks

This study shows IVH reduces ciliated ependymal cells but does not disrupt cilia function or CSF flow networks in the lateral ventricles.

Multi-omics profiling of mouse polycystic kidney disease progression at a single cell resolution

This study uses single-nucleus multi-omics to analyze mouse PKD progression, identifying cell-type-specific gene and epigenetic changes and conserved regulatory pathways between mouse and human.

Ultrastructure expansion microscopy (U-ExM) of mouse and human kidneys for analysis of subcellular structures

This paper describes a U-ExM protocol for analyzing subcellular structures in mouse and human kidney tissues with high detail using conventional microscopy.

Aberrant centrosome biogenesis disrupts nephron progenitor cell renewal and fate resulting in fibrocystic kidney disease

This study shows that disrupting centrosome biogenesis in nephron progenitor cells causes kidney developmental defects and fibrocystic disease through reduced cell populations, premature differentiation, and altered signaling pathways.

Impaired centrosome biogenesis in kidney stromal progenitors reduces abundance of interstitial lineages and accelerates injury-induced fibrosis

This study shows that impaired centrosome biogenesis in kidney stromal progenitors reduces interstitial cell abundance and accelerates fibrosis after injury.

Inhibition of Centrosome Clustering Reduces Cystogenesis and Improves Kidney Function in Autosomal Dominant Polycystic Kidney Disease

This study shows that inhibiting centrosome clustering reduces cyst growth and improves kidney function in ADPKD by activating p53-mediated apoptosis.

Super-resolution Molecular Map of Basal Foot Reveals Novel Cilium in Airway Multiciliated Cells

The paper uses super-resolution imaging to reveal a novel hybrid cilium in airway multiciliated cells and its role as a signaling center.