Developmental BiologybioRxivPreprint
Aberrant centrosome biogenesis disrupts nephron progenitor cell renewal and fate resulting in fibrocystic kidney disease
Tao Cheng, Chidera Agwu, Kyuhwan Shim…·Moe R. Mahjoub
This study shows that disrupting centrosome biogenesis in nephron progenitor cells causes kidney developmental defects and fibrocystic disease through reduced cell populations, premature differentiation, and altered signaling pathways.
DOI 10.1101/2023.04.04.535568