Sanjay R. Jain

This study identifies three sequential stages of actomyosin remodeling in podocyte injury across multiple kidney diseases, suggesting a structured, potentially reversible response.

Pan-human Azimuth maps diverse human cells into a unified hierarchical typology, enabling cross-tissue comparisons and spatial transcriptomic annotation.

DigitAb predicts cell types from H&E-stained slides using deep learning, achieving high accuracy without specialized assays or immunostains.

This paper identifies repurposed drugs that improve endothelial function in COL4A1-related disorders using in vitro and in vivo models.

This study identifies a MEF2C transcription factor network that regulates endothelial cell proliferation in diabetic kidney disease and shows that SGLT2i treatment can reverse its dysregulation.

NetTracer3D provides a tool for analyzing 3D tissue maps from diverse datasets, enabling network-based exploration of spatial relationships and tissue organization.

This study shows that hPSC-derived distal nephron epithelium can adopt ureteric or nephric duct-like identities in vitro in response to extracellular signals.

The paper builds a cross-species single-cell multi-omics kidney atlas to identify epithelial cells as a driver of epigenetic aging in diseased kidneys.

The paper presents a multi-modal atlas of human kidney disease, identifying cellular and spatial mechanisms of injury resolution or failure and linking them to clinical outcomes.

FUSION is a web-based tool that integrates spatial -omics data with histology to analyze tissue states and identify spatial linkages between molecular and histopathologic features.

This paper constructs a 3D map of neurovascular nephron connectivity in the human kidney across the lifespan and identifies structural changes in development and disease.

This paper uses label-free imaging to analyze biomolecular and morphological features of diabetic kidney tissue in 2D and 3D, revealing distinct markers not previously observed.

This paper describes the construction and usage of the Human Reference Atlas (HRA) v2.0, which integrates multiscale data across 36 organs and provides tools for analysis and visualization.

This study shows that NAD+ supplementation protects against CKD in Alport syndrome by restoring FAO in proximal tubule cells and reveals sex differences in transcriptional responses.

The paper uses ontologies to integrate clinical, pathological, and molecular kidney data for precision medicine analysis.

The paper introduces DART-FISH, a multiplexed RNA in situ hybridization technique for high-resolution profiling of human tissues, demonstrating its application on brain and kidney samples.

This study shows that disrupting centrosome biogenesis in nephron progenitor cells causes kidney developmental defects and fibrocystic disease through reduced cell populations, premature differentiation, and altered signaling pathways.

The paper presents software tools and user interfaces for annotating and exploring tissue data in a human reference atlas, enabling data harmonization and public access.

This study maps the spatial transcriptomic landscape of the human kidney papilla in stone disease, identifying immune injury and matrix remodeling as key features.

The paper constructs a reference tissue atlas of the human kidney using multi-omics data to identify cell types, pathways, and genes across nephron segments and interstitium.

This study identifies macrophage AT2R activation as a key driver of neuropathic pain through ROS/NO-mediated TRPA1 activation in sensory neurons.