Heme orchestrates a tissue stress response to proteolytic damage
Karen Agaronyan, Allison Marie Greaney, Shuang Yu, Arun Rajendra Chavan, Darine W. El-Naccache, Edward P. Manning, L Sharma, Charles S. Dela Cruz, Ruslan M. Medzhitov
The paper identifies a conserved tissue-level stress response to proteolytic damage, characterized by heme release and oxidative stress, and shows how alveolar macrophages and fibroblasts respond to mitigate damage.
bioRxiv · Jun 7, 2026 · PreprintImmunology