Arun Rajendra Chavan

The paper shows macrophages remove protein aggregates from other cells via trogocytosis, driven by lysosomal stress and tmCSF1 signaling.

The paper identifies a conserved tissue-level stress response to proteolytic damage, characterized by heme release and oxidative stress, and shows how alveolar macrophages and fibroblasts respond to mitigate damage.

The paper reconstructs the evolutionary history of neonatal maturity in mammals and finds that the eutherian ancestor likely gave birth to precocial neonates, challenging the idea that precociality evolved multiple times within eutherians.