Ruslan M. Medzhitov

Non-cell-autonomous removal of protein aggregates via trogocytosis

The paper shows macrophages remove protein aggregates from other cells via trogocytosis, driven by lysosomal stress and tmCSF1 signaling.

Heme orchestrates a tissue stress response to proteolytic damage

The paper identifies a conserved tissue-level stress response to proteolytic damage, characterized by heme release and oxidative stress, and shows how alveolar macrophages and fibroblasts respond to mitigate damage.

A stress-function tradeoff organizes epithelial heterogeneity across spatial scales in the human thyroid

The paper uses spatial transcriptomics to analyze thyroid heterogeneity, identifying a damage-response thyrocyte state that balances with hormone-producing states across scales.

Interplay between the immune response and the adaptation of metabolic pathways upon infection

The paper develops a mathematical model to study how immune responses and metabolic pathway adaptations interact during infection, finding that glucose redistribution and cytokine regulation are critical for effective pathogen clearance.

Circuit to target approach defines an autocrine myofibroblast loop that drives cardiac fibrosis

The paper models a macrophage-myofibroblast circuit to predict fibrosis types and shows targeting the myofibroblast autocrine loop reduces fibrosis after myocardial infarction.

Recurrent hyper-motif circuits in developmental programs

The paper develops a framework to analyze developmental circuits using single-cell gene expression data from the human intestine, revealing design principles of developmental programs.

Engineered Whole Lungs for Tissue Biology

This study develops an engineered whole-lung tissue model to study tissue organization and alveolar barrier function, showing improved barrier function with alveolar macrophages.

Emergence of division of labor in tissues through cell interactions and spatial cues

The paper develops a computational framework to study division of labor in tissues by analyzing cell interactions and spatial cues using single-cell RNA-seq and spatial transcriptomics data.

Principles of Cell Circuits for Tissue Repair and Fibrosis

This study identifies a cell-circuit framework for wound healing and fibrosis, revealing three fibrosis outcomes and parameters that control the transition from healing to fibrosis.