ImmunologybioRxiv
The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.
A. a. Aybar-Torres, L. A. saldarriaga, A. T. Pham…·l. jin
This study shows that common TMEM173 alleles HAQ and AQ reduce inflammation in SAVI mice by preventing CD4 T cell depletion and restoring T-regs.
DOI 10.7554/elife.96790.3