Pharmacological inhibition of the heart of glass (HEG1)-Krev interaction trapped protein 1 (KRIT1) protein complex increases Kruppel-like Factors 4 and 2 (KLF4/2) expression in endothelial cells
M. A. Lopez-Ramirez, M. K. Haynes, P. Hale, K. Oukoloff, M. Bautista, B. Gongol, J. Y. Shyy, C. Ballatore, L. A. Sklar, A. R. Gingras
This study identifies inhibitors of the HEG1-KRIT1 interaction that increase KLF4/2 expression in endothelial cells, leading to upregulation of thrombomodulin and downregulation of thrombospondin.
bioRxiv · Aug 23, 2019 · PreprintBiochemistry