Mapping molecular determinants of Cav2.2 inhibition by RGK proteins and homologs in Xenopus oocytes
Y. Sasson, S. Subramaniam, T. Buki, L. Almagor, O. Chomsky-Hecht, M. Katz, H. Puhl, S. R. Ikeda, N. Dascal, J. Hirsch
This study identifies structural determinants in RGK proteins that inhibit CaV2.2 channels in Xenopus oocytes, showing key regions in the G-domain and C-terminus are critical for this inhibition.
bioRxiv · Jun 21, 2022 · PreprintPhysiology