Author

O. Chomsky-Hecht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:electrophysiology· 2 Organism:Xenopus· 2

Frequent Co-Authors

M. Katz· 3 shared N. Dascal· 3 shared E. Klussmann· 2 shared J. Hirsch· 2 shared S. Subramaniam· 2 shared S. Weiss· 2 shared V. Flockerzi· 2 shared V. Tsemakhovich· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersPhysiology

M. Katz

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3 papers

Recent·Most cited

Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel modulate its β-adrenergic regulation

S. Oz, T. Sharon, S. Surbramaniam, T. Pallien, M. Katz, V. Tsemakhovich, D. R. Tripathy, G. Sasson, O. Chomsky-Hecht, L. Vysochek, M. Schulz, C. Fecher-Trost, K. Zuhlke, D. Bertinetti, F. W. Herberg, , N. Dascal

This study identifies direct interactions between PKA catalytic subunit and C-terminal domains of cardiac CaV1.2 channels, revealing their role in modulating β-adrenergic regulation.

bioRxiv · Nov 28, 2023 · PreprintBiochemistry

Mapping molecular determinants of Cav2.2 inhibition by RGK proteins and homologs in Xenopus oocytes

Y. Sasson, S. Subramaniam, T. Buki, L. Almagor, O. Chomsky-Hecht, M. Katz, H. Puhl, S. R. Ikeda, N. Dascal, J. Hirsch

This study identifies structural determinants in RGK proteins that inhibit CaV2.2 channels in Xenopus oocytes, showing key regions in the G-domain and C-terminus are critical for this inhibition.

bioRxiv · Jun 21, 2022 · PreprintPhysiology

Reconstitution of β-adrenergic regulation of CaV1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.

M. Katz, S. Subramaniam, O. Chomsky-Hecht, V. Tsemakhovich, A. Belkacemi, V. Flockerzi, E. Klussmann, J. Hirsch, S. Weiss, N. Dascal

This study reconstitutes the β-adrenergic regulation of CaV1.2 channels in a heterologous system, identifying Rad-dependent and Rad-independent PKA mechanisms.

bioRxiv · Nov 30, 2020Physiology